SARS相关冠状病毒与其他已知冠状病毒的膜蛋白的多序列联配

• 作 者: 史定华 周晖杰 王斌宾 顾燕红 王翼飞
• 机 构: Department of Mathematics, Shanghai University, Shanghai 200436, China
• 出 处: 上海大学学报(英文版)
• 发表日期: 2003年2期
• 关键词: SARS (Severe Acute Respiratory Syndrome) coronavirus M (Membrane or Matrix) prot

In this paper, we report a multiple sequence alignment result on the basis of 10 amino acid sequences of the M protein,which come from different coronaviruses (4 SARS-associated and 6 others known). The alignment model was based on the profileHMM (Hidden Markov Model), and the model training was implemented through the SAHMM (Self-Adapting Hidden Markov Model)software developed by the authors.