Synthesis and evaluation of 64Cu-radiolabeled NOTA-cetuximab(64Cu-NOTA-C225) for immuno-PET imaging

• 作 者: Xiaoxia Xu Teli Liu Fei Liu Xi
• 机 构: KeyLaboratoryofCarcinogenesisandTranslationalResearch（MinistryofEducation/Beijing）,DepartmentofOrtho
• 出 处: 中国癌症研究:英文版
• 发表日期: 2019年2期
• 关键词: EPIDERMAL growth factor receptor immuno-PET imaging copper-64 monoclonal antibod
• 基金项目: Natural Science Foundation of Beijing Municipality (No. 7162041),Beijing Nova program (No. Z171100001117020),Beijing Municipal Commission of Health and Family Planning (215 backbone program No. 2015-3

Objective: Epidermal growth factor receptor(EGFR) is overexpressed in a wide variety of solid tumors, serving as a well-characterized target for cancer imaging or therapy. In this study, we aimed to design and synthesize a radiotracer, 64 Cu-NOTA-C225, ta