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特发性肺含铁血黄素沉着症(简称IPH)临床上有咯血、肺部广泛实质浸润、以及缺铁性贫血3种特征。虽经实验、形态、免疫和超微结构等许多研究,至今病因未明。本文作者报导30例IPH患儿的流行病学调查。作者将希腊Salonica医学校儿科临床20年(1957～1976)来诊断为IPH的30例进行复查。本院为希腊北部的儿科咨询机构,为大约300万人口服务,30%人口居住在乡间,而不到10,000人口住在城镇,确诊根据是3种特征性的症状和肺活检。肺活检示不明原因的肺出血,无血管炎性变或肉芽肿。所有病例均在该院随访,无一例发生肺外疾病。对所有病例进行家访,详细询问病史、围生史、预防接种史、家族史、饮食习惯、发病季节、地理分布;重点放在居住条件方面。
Idiopathic pulmonary hemosiderosis (referred to as IPH) clinically hemoptysis, extensive extensive lung invasion, and three characteristics of iron deficiency anemia. Although many experiments, morphological, immunological and ultrastructural studies, the etiology has not yet been identified. The authors report the epidemiological investigation of 30 children with IPH. The authors reviewed the 30 cases diagnosed with IPH in the pediatric department of Salonica Medical School in Greece for 20 years (1957-1976). The hospital is a pediatric consultancy in northern Greece serving about 3 million people, 30% of the population living in the country, and less than 10,000 in urban areas. The diagnosis is based on 3 characteristic symptoms and lung biopsy. Pulmonary biopsy showed unexplained pulmonary hemorrhage, avascular inflammation or granuloma. All cases were followed up in the hospital, no case of extrapulmonary disease. Home visits in all cases, detailed history, peripartum history, vaccination history, family history, diet, onset season, geographical distribution; with emphasis on living conditions.