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近10多年来对疟疾患者的循环免疫复合物和沉积在组织的免疫复合物进行了较广泛的研究,因而对疟疾病变及其临床症状的免疫病理学机理的认识取得了很大的进展。 免疫复合物的形成乃正常免疫应答的组成部份,只有当效应系统不适当地激活或失活时才有可能产生病理性后果,而导致免疫复合物疾病。疟疾时免疫复合物可能以下列方式参与疟疾的免疫病理学变化;①激活激肽、补体等介质系统导致凝血;②免疫复合物沉积在组织或细胞(例如红细胞)表面;③抑
In the past more than 10 years, the circulating immune complexes of malaria patients and the immune complexes deposited in the tissues have been extensively studied. Therefore, great progress has been made in understanding the immunopathological mechanisms of malaria lesions and their clinical symptoms. The formation of immune complexes is an integral part of the normal immune response and is only likely to have pathological consequences if the effector system is not properly activated or inactivated, resulting in an immune complex disease. Immune complexes in malaria may be involved in the immunopathological changes in malaria in the following ways: (1) Activation of media systems such as kinins and complement cause coagulation; (2) Immune complexes deposit on the surface of tissues or cells (eg red blood cells);