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目的：分析铜绿假单胞菌( PA)临床分离株的耐药性，为PA感染的临床治疗提供依据。方法：回顾性调查某医院2012年1~12月PA感染情况，对分离出的448株PAE药敏试验结果进行统计分析。结果：448株铜绿假单胞菌对药物敏感率依次为头孢哌酮/舒巴坦、氨苄西林/舒巴坦100%，环丙沙星76%，头孢吡肟72.8%，哌拉西林/他唑巴坦69.4%，阿米卡星66.3%，头孢他啶65.6%，美罗培南64.8%，亚胺培南59.9%，米诺环素28.9%，复方磺胺甲噁唑2.4%和头孢呋辛0%。结论：PA是医院感染的主要病原菌之一，应对其加强耐药性监测，规范抗菌药物的应用，为临床合理应用抗菌药物提供参考。“,”Objective:To analyze the drug resistance of Pseudomonas aeruginosa( PA) isolated from clinical specimen to provide the guidance for the clinical treatment. Methods:The infection status of PA from January 2012 to December 2012 was reviewed retro-spectively, and the results of susceptibility test for 448 PA strains were analyzed. Results:The antibiotic susceptibility of the PA strains to cefoperazone sodium and sulbac, ampicillin aodium and aulbacta,aiprofloxacin,cefepime,piperacillin/ sulbactam,amikacin, ceftazi-dime,meropenem, imipenem, minocycline, selectrin and aefuroxime was 100%, 76%, 72. 8%, 69. 4%, 66. 3%, 65. 6%, 64. 8%, 59. 9%,28. 9%,2. 4% and 0%,respectively. Conclusion:PA is one of the main pathogenic bacteria for nosocomial infection. It is necessary to strengthen the drug resistance test and standardize the application of antibiotics in order to provide the reference for clinical rational use of antibacterial drugs.