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肝脏移植、肝脏大部分切除术在临床上极为常见,术中需要阻断下腔静脉、门静脉及肝动脉的血流,造成全肝缺血再灌注损伤,不仅影响肝脏本身功能[1],对远隔脏器——心脏也会造成损伤[2-4]。因此,建立一种稳定、简单经济的全肝缺血再灌注损伤动物模型,对于研究其发生机制、预防及治疗具有重要意义。本研究以SD大鼠为研究对象,采用微型无损伤血管夹夹闭肝固有动脉、门静脉、胆总管的方法制备100%
Liver transplantation, resection of the liver most of the clinically very common, intraoperative need to block the inferior vena cava, portal vein and hepatic artery blood flow, resulting in whole liver ischemia-reperfusion injury, not only affect the function of the liver itself [1], the Distant organs - the heart can cause damage [2-4]. Therefore, to establish a stable, simple and economical animal model of total hepatic ischemia-reperfusion injury is of great significance for studying its mechanism, prevention and treatment. In this study, SD rats as the research object, the use of mini-non-invasive vascular clamp closed hepatic artery, portal vein, common bile duct preparation of 100%