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目的:探讨Ⅳ期乳腺癌局部-区域治疗的方法、意义及对患者生存期的影响。方法:应用PubMed、CNKI及万方期刊全文数据库检索系统,以“乳腺肿瘤、Ⅳ期”和“局部治疗”或“区域治疗”等为关键词,检索2000-01-2012-10的相关文献。纳入标准:1)Ⅳ期乳腺癌局部-区域治疗的预后;2)Ⅳ期乳腺癌局部-区域治疗的措施及意义。根据纳入的标准,精选39篇文献进行分析。结果:Ⅳ期乳腺癌的局部-区域治疗可提高乳腺癌患者的中位生存时间;局部-区域治疗主要是通过手术或者局部放疗及两者联合的治疗方法来根治原发病灶,或减小肿瘤负荷、获得更详细的临床病理资料,同时局部治疗的介入也使综合治疗的顺应性更好,在一定程度上减轻患者的心理负担。结论:Ⅳ期乳腺癌在全身治疗的基础上,局部-区域治疗适时、适度的介入,是延长Ⅳ期乳腺癌患者的生存时间,改善患者的生活质量有效的治疗措施之一。
Objective: To explore the method and significance of local-regional treatment for stage IV breast cancer and its impact on the survival of patients. Methods: Using PubMed, CNKI and Wanfung periodicals full-text database retrieval system, the key words of “Breast neoplasms, stage Ⅳ” and “local treatment” or “regional treatment” were searched. -10 related articles. Inclusion criteria: 1) prognosis of local-regional treatment of stage IV breast cancer; and 2) measures and significance of local-regional treatment of stage IV breast cancer. Based on the included criteria, 39 articles were selected for analysis. Results: The regional-regional treatment of stage IV breast cancer can improve the median survival time of patients with breast cancer. The treatment of local-regional mainly by primary surgery or local radiotherapy and the combination of the two methods to cure the primary lesion or reduce the tumor Load, access to more detailed clinical and pathological data, while the local treatment intervention also makes the comprehensive treatment of compliance better, to some extent, reduce the psychological burden on patients. Conclusion: Based on systemic therapy, stage Ⅳ breast cancer is timely and appropriate intervention. It is one of the effective measures to prolong the survival time and improve the quality of life of patients with stage Ⅳ breast cancer.