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INTRODUCTIONChronic hepatitis B virus(HBV)infection is aserious problem because of its worldwidedistribution and possible adverse sequelae,such ascirrhosis and hepatocellular carcinoma(HCC).The World Health Organization estimates that HBVhas infected more than 350 million peopleworldwide,and up to 20% of those infected with
INTRODUCTIONChronic hepatitis B virus (HBV) infection is a serious problem because of its world investment and likely adverse sequelae, such as ascirrhosis and hepatocellular carcinoma (HCC). The World Health Organization estimates that HBVhas infected more than 350 million peopleworldwide, and up to 20% of those infected with