论文部分内容阅读
目的探究不同药物对类风湿关节炎患者血清中硒、铜、锌含量的影响。方法 100例类风湿关节炎患者(病例组)及40例健康体检者(对照组),根据治疗药物不同将100例病例组患者分为A、B、C、D、E组,每组20例,其中A组采用柳氮磺吡啶治疗,B组采用糖皮质激素治疗,C组采用甲氨蝶呤治疗,D组采用非甾体类抗炎药治疗,E组采用羟氯喹治疗。观察患者治疗前后血清中硒、铜、锌的含量的变化。结果治疗前,病例组患者血清中铜水平高于对照组,硒、锌水平低于对照组,差异均具有统计学意义(P<0.05)。治疗后,C组血清中锌水平高于治疗前,差异具有统计学意义(P<0.05)。A、B、D、E组治疗前后血清中硒、铜、锌水平无明显变化,差异无统计学意义(P>0.05)。结论在类风湿关节炎进展过程中,血清中硒、铜、锌可能参与其中。甲氨蝶呤能够改善患者免疫状态,可作为临床治疗的首选药物。
Objective To investigate the effects of different drugs on serum selenium, copper and zinc in patients with rheumatoid arthritis. Methods 100 patients with rheumatoid arthritis (case group) and 40 healthy subjects (control group) were divided into A, B, C, D and E groups according to different therapeutic drugs. Each group included 20 patients , In which group A was treated with sulfasalazine, group B was treated with glucocorticoid, group C was treated with methotrexate, group D was treated with non-steroidal anti-inflammatory drugs, and group E was treated with hydroxychloroquine. Changes of selenium, copper and zinc in serum before and after treatment were observed. Results Before treatment, the level of copper in the serum of patients in the case group was higher than that of the control group, while the level of selenium and zinc was lower than that of the control group (P <0.05). After treatment, serum zinc in group C was higher than that before treatment, the difference was statistically significant (P <0.05). Serum selenium, copper and zinc levels in groups A, B, D and E had no significant changes before and after treatment, with no significant difference (P> 0.05). Conclusion In the process of rheumatoid arthritis, serum selenium, copper, zinc may be involved. Methotrexate can improve the patient’s immune status, as the drug of choice for clinical treatment.