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目的探讨黄姜水提取物(WED)对由高脂高胆固醇致家兔动脉粥样硬化的影响。方法采用高脂高胆固醇饲喂法建立家兔动脉粥样硬化模型,分别测定正常对照组、高脂模型组、WED低、中、高剂量组血清中TC、TG、LDL-C、HDL-C、MDA的含量及SOD的活性,采用大体染色计算脂肪斑块面积、组织切片观察。结果 WED均能明显降低血清中TC、TG、LDL-C、MDA的含量(P<0.01),并能升高血清中HDL-C的含量(P<0.01)和SOD的活性(P<0.05),中、高剂量组家兔粥样斑块腹主动脉前段脂质面积百分比值与高脂模型组比较具有统计意义,分别为40.71%±9.13%(P<0.05)、35.24%±3.09%(P<0.01)、76.54%±19.53%;病理切片显示:各用药组家兔主动脉病变程度均小于高脂模型组,其中高剂量组的AS病变程度最小。结论 DWS具有抗高脂饮食诱导家兔动脉粥样硬化的作用,其作用机制可能与其调节血脂与抗脂质过氧化有关。
Objective To investigate the effects of turmeric water extract (WED) on atherosclerosis in rabbits induced by high fat and cholesterol. Methods The model of atherosclerosis in rabbits was established by high-fat and high-cholesterol feeding. The contents of TC, TG, LDL-C and HDL-C in serum of normal control group, high fat model group, WED low, , The content of MDA and the activity of SOD, gross staining was used to calculate the area of plaque and histological sections were observed. Results WED significantly decreased the levels of TC, TG, LDL-C and MDA in serum (P <0.01) and increased the content of HDL-C in serum (P <0.01) and the activity of SOD The percentage of lipid area in the anterior abdominal aorta in rabbits with atherosclerotic plaque was significantly higher than that in the model group (40.71% ± 9.13%, 35.24% ± 3.09%, respectively) P <0.01), 76.54% ± 19.53%. Pathological examination showed that the pathological changes of aorta of rabbits in each drug group were less than those in high fat model group, and the high dose group had the least degree of AS lesion. Conclusion DWS can induce atherosclerosis in rabbits induced by high-fat diet. Its mechanism may be related to the regulation of blood lipid and anti-lipid peroxidation.