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5-Fluorouracil(5-FU) loaded nanoparticles(NPs) were prepared by a high speed shearing double emulsion method with polylactide-co-glycolide-co-methoxy poly(ethylene glycol)(PLGA-mPEG) as loading material. The prepared NPs possess a negative zeta potential and their loading efficiency is about 15%(mass fraction). The result of in vitro release shows that the release behavior of 5-FU from NPs is coincident with Zero-level release from the second day.
5-Fluorouracil (5-FU) loaded nanoparticles (NPs) were prepared by a high speed shearing double emulsion method with polylactide-co-glycolide-co-methoxy poly possess a negative zeta potential and their loading efficiency is about 15% (mass fraction). The result of in vitro release shows that the release behavior of 5-FU from NPs is coincident with zero-level release from the second day.