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目的探讨CDK4和ki67在子宫内膜癌组织中的表达及其意义。方法选取2007年2月—2013年5月邯郸市中医院和邯郸市妇幼保健院妇科收治的子宫内膜癌患者60例,另外选取同期子宫肌瘤或子宫脱垂而手术切除子宫的正常子宫内膜标本(均为分泌期子宫内膜)32例,应用免疫组化染色SP法检测两种组织中CDK4和ki67的表达情况。结果 CDK4和ki67在子宫内膜癌组织中的阳性表达率高于正常子宫内膜组织(P<0.05);在组织学分级G2~G3级、临床分期Ⅲ~Ⅳ期、有淋巴结转移的子宫内膜癌组织中CDK4和ki67的阳性表达率分别高于组织学分级G1级、临床分期Ⅰ~Ⅱ期、无淋巴结转移患者(P<0.05);在子宫内膜癌组织中CDK4和ki67的表达呈正相关(r=0.459,P<0.05)。结论 CDK4和ki67在子宫内膜癌组织中呈高表达,且与子宫内膜癌的发生、发展和转移具有一定的关系。
Objective To investigate the expression and significance of CDK4 and ki67 in endometrial carcinoma. Methods From February 2007 to May 2013, 60 patients with endometrial cancer underwent gynecology in Handan Hospital of Traditional Chinese Medicine and Handan Maternal and Child Health Hospital, 60 cases of endometrial cancer were selected from the same period of uterine fibroids or uterine prolapse and the normal uterus Thirty-two cases of membranous endometrium were secreted, and the expression of CDK4 and ki67 in both tissues were detected by immunohistochemical SP method. Results The positive rates of CDK4 and ki67 in endometrial carcinoma were significantly higher than those in normal endometrial tissues (P <0.05). In the histological grade G2 to G3, clinical stage Ⅲ to Ⅳ, the intrauterine lymph node metastasis The positive expression rates of CDK4 and ki67 in the cancer tissues were higher than those in the histological grade G1, clinical stage Ⅰ-Ⅱ, and without lymph node metastasis (P <0.05), respectively. The positive expressions of CDK4 and ki67 in the endometrial carcinoma tissues were positive (R = 0.459, P <0.05). Conclusion CDK4 and ki67 are highly expressed in endometrial carcinoma and have a relationship with the occurrence, development and metastasis of endometrial carcinoma.