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目的分析高血压患者的血压变异性(blood pressure variability,BPV)的相关因素,探讨其控制与治疗方法。方法运用多元回归分析法确定血压变异型的独立相关因素,随机分为两组,对照组560例给予非洛地平降压治疗,观察组570例给予苯磺酸氨氯地平降压治疗,观察两种药物对BPV的影响。结果 SBPV独立相关因素有24hSBP、载脂蛋白A1、载脂蛋白B100、甘油三酯、年龄、性别、尿酸;DBPV的独立相关因素有24hDBP、年龄、体重指数、载脂蛋白A1、载脂蛋白B100。苯磺酸氨氯地平在控制BPV方面优于非洛地平,治疗后观察组SBPV与DBPV分别为(10.3±2.8)mm Hg(1 mm Hg=0.133 kPa)、(5.9±2.1)mm Hg,与对照组比较差异有统计学意义(P<0.05)。结论降低血压和血脂水平,控制体重和尿酸水平可以有效地控制高血压患者的BPV,减少器官损伤。苯磺酸氨氯地平片能有效降低BPV,是治疗高血压比较有效的药物。
Objective To analyze the related factors of blood pressure variability (BPV) in hypertensive patients and to explore its control and treatment methods. MethodsMultivariate regression analysis was used to determine the independent correlates of blood pressure variability and were randomly divided into two groups. 560 cases in the control group were given antihypertensive treatment of felodipine, and 570 cases in the observation group were given antihypertensive treatment with amlodipine besylate The impact of drugs on BPV. Results SBPV independent factors 24hSBP, apolipoprotein A1, apolipoprotein B100, triglyceride, age, gender, uric acid; DBPV independent factors associated with 24hDBP, age, body mass index, apolipoprotein A1, apolipoprotein B100 . Amlodipine besylate is superior to felodipine in the control of BPV. After treatment, SBPV and DBPV in the observation group were (10.3 ± 2.8) mm Hg (1 mm Hg = 0.133 kPa) and 5.9 ± 2.1 mm Hg The difference between the control group was statistically significant (P <0.05). Conclusions Lowering blood pressure and blood lipids, controlling body weight and uric acid levels can effectively control BPV in hypertensive patients and reduce organ damage. Amlodipine besylate tablets can effectively reduce BPV, is more effective in the treatment of hypertension drugs.