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病理学和流行病学研究表明不利的母体内环境,如母体蛋白质摄入不足、高胆固醇血症、糖尿病(DM)、吸烟等,均可增加子代发生心血管疾病的风险。在子宫内,胎盘和胎儿直接接收来自母体的多种代谢信号:抗氧化剂及促炎、抗炎信息等,并产生特异性应答,致使胚胎DNA甲基化、染色体修饰等过程发生改变,对子代产生持久性的影响,继而导致胎儿成年后动脉粥样硬化(AS)的易感性增强。文中就母体不利因素对子代发生动脉粥样硬化危险性的影响及其相关信号传递和作用机制作一综述。
Pathological and epidemiological studies have shown that adverse maternal conditions, such as maternal protein insufficiency, hypercholesterolemia, diabetes mellitus (DM), smoking, etc., may increase the risk of developing cardiovascular disease in offspring. In the uterus, the placenta and fetus directly receive a variety of metabolic signals from the mother: antioxidants and proinflammatory and anti-inflammatory information, and generate specific responses, resulting in embryonic DNA methylation, chromosome modification and other processes change, Generation of persistent effects, which in turn lead to increased susceptibility to atherosclerosis (AS) in the adult fetus. In this article, the adverse effects of maternal factors on the risk of atherosclerosis in offspring and its related signal transduction and mechanism were reviewed.