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植物血凝素(Phytohemagglutinin简称PHA)是从红肾豆中提取的一种糖蛋白。本世纪初发现PHA对人和动物的红细胞有凝集作用。1960年Nowen报导PHA加入营养的淋巴细胞液中,能促使淋巴细胞分裂。1964年Robbins报告在PHA的作用下,营养的小淋巴细胞可以转化为淋巴母细胞以后进行细胞分裂。国内浙江医科大学1972年首先报告应用于临床。1973年广东省医药工业研究所从广东菜豆中提取一种糖蛋白为低聚糖和蛋白质的复合大分子物质(即PHA)并于1975年将广东省医药工业研究所生产的PHA凉干注射剂应用于临床。PHA配合药物治疗血液系统疾病,PHA配合其他疗法治疗实体瘤,以及在传染科中应用治疗流行性出血热,病毒性肝炎,麻风等皆取得了不同程度的效果。我们采用PHA治疗迁延性肝炎、慢性肝炎50例收到满意效果,现报告如下:
Phytohemagglutinin (PHA) is a glycoprotein extracted from red kidney beans. The beginning of this century found that PHA on human and animal erythrocyte agglutination. Nowen 1960 reported PHA added to the nutrient solution of lymphocytes, can promote lymphocyte division. In 1964, Robbins reported that under the action of PHA, vegetative small lymphocytes can be transformed into lymphoblasts and then undergo cell division. Zhejiang Medical University in 1972 first reported for clinical application. In 1973, Guangdong Institute of Pharmaceutical Industry extracted a composite macromolecule substance (namely PHA) with glycoproteins of oligosaccharides and proteins from Cantonese bean and applied PHA dry-dry injection manufactured by Guangdong Institute of Pharmaceutical Industry in 1975 In clinical. PHA with drug treatment of hematological diseases, PHA with other therapies for solid tumors, as well as in infectious diseases in the treatment of epidemic hemorrhagic fever, viral hepatitis, leprosy Dengjun achieved varying degrees of effect. We use PHA treatment of persistent hepatitis, 50 cases of chronic hepatitis received satisfactory results, are as follows: