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本文对61名接触氟仿工人和23名无明显毒物接触史的对照组工人进行了初步的职业流行病学调查研究。作业车间空气中氯仿浓度的几何均数分别为13.40和29.51mg/m~3。接触工人的健康检查结果表明,29.51 mg/m~3的浓度可引起接触者乏力、嗜睡等症状检出率增高及肝脏合成蛋白的能力降低,表现为血清前白蛋白、转铁蛋白含量异常率明显高于对照组(分别为46.8%vs13%,76.6%vs43.5%)。以血清BUN含量为指标,未发现肾脏功能受损。初步认为,若以30mg/m~3为长期慢性接触氟仿的阈浓度,取1.5～2.0的安全系数,氟仿的最高容许浓度应在15～20 mg/m~3。并建议对血清前白蛋白、转铁蛋白含量测定作为慢性中毒性肝病的应用价值进行进一步的研究。
This article conducted a preliminary occupational epidemiological investigation of 61 workers exposed to fluorofluorocarbons and 23 controls who had no history of exposure to poisons. The geometric mean concentrations of chloroform in the air of the workshop were 13.40 and 29.51 mg / m ~ 3, respectively. Exposure to workers’ health examination results showed that the concentration of 29.51 mg / m 3 could cause contact fatigue, increased symptoms of lethargy and decreased liver synthesis of protein, manifested as pre-serum albumin, transferrin abnormalities Was significantly higher than the control group (46.8% vs13%, 76.6% vs43.5%, respectively). Serum BUN levels as an indicator, did not find impaired renal function. It is preliminarily believed that if the threshold concentration of chronic exposure to fluoroform is 30 mg / m ~ 3 and the safety factor of 1.5 ~ 2.0 is adopted, the maximum allowable concentration of fluoroform should be 15-20 mg / m ~ 3. And it is suggested that the serum albumin, transferrin content as a chronic toxic liver disease value for further study.