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目的比较心绞痛患者经介入治疗、药物治疗的长期效果。方法调查对象为本院收治的不稳定型心绞痛患者108例,用前瞻性随机对照试验方法,给予药物组(n=54)药物治疗,介入组(n=54)患者均接受经皮冠状动脉介入治疗;所有患者随访12～24个月,记录心绞痛、急性心肌梗死(AMI)发生率、病死率,随访结束用西雅图心绞痛调查量表(SAQ)评估两组患者的生活质量。结果随访12个月,药物组再发心绞痛24例(24/54,44.4%),介入组再发心绞痛11例(24/54,20.4%),两组有显著性差异(P<0.05);随访24个月,药物组再发心绞痛19例(19/52,36.5%),介入组再发心绞痛8例(8/52,15.4%),两组有显著性差异(P<0.05);两组的AMI发生率及死亡率均无显著性差异(P>0.05);随访第12个月,介入组SAQ评分明显优于药物组(P<0.05)。结论冠状动脉介入治疗不稳定型心绞痛的临床效果显著,有利于改善患者的生活质量。
Objective To compare the long-term effects of interventional therapy and drug therapy in patients with angina pectoris. Methods A total of 108 patients with unstable angina pectoris admitted to our hospital were enrolled in the study. Patients were randomized to receive medication (n = 54) in a prospective randomized controlled trial. Patients in the intervention group (n = 54) underwent percutaneous coronary intervention All patients were followed up for 12-24 months. The incidence of angina pectoris, acute myocardial infarction (AMI) and mortality were recorded. At the end of follow-up, the Seattle Angina Symptom Inventory (SAQ) was used to evaluate the quality of life of both groups. The results were followed up for 12 months. There were 24 patients (24/54, 44.4%) with recurrence of angina in the drug group and 11 patients (24/54, 20.4%) with recurrence of angina in the intervention group. There was significant difference between the two groups (P <0.05). During the 24 months follow-up, 19 cases (19/52, 36.5%) had recurrence of angina in the drug group and 8 cases (8/52, 15.4%) had recurrence of angina in the intervention group. There was significant difference between the two groups (P <0.05) There was no significant difference in the incidence of AMI and mortality between the two groups (P> 0.05). At the 12th month after follow-up, the SAQ score of the intervention group was significantly better than that of the drug group (P <0.05). Conclusion The clinical effect of coronary intervention in the treatment of unstable angina pectoris is significant, which is beneficial to improve the quality of life of patients.