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目的:探讨子痫前期孕妇血清、胎盘组织MMP-9及NGAL表达的变化情况。方法:回顾性分析100例子痫前期孕妇的临床资料,依据临床分型不同分为早发型组40例,晚发型组60例。另选同期正常妊娠妇女50例作为对照组。结果:早发型组和晚发型组的血清中MMP-9、NGAL的表达均明显高于对照组(t=18.00,t=19.55,P<0.05),且早发型组高于晚发型组(t=10.33,P<0.05)。早发型组和晚发型组的胎盘组织中MMP-9 mRNA、NGAL mRNA均低于对照组(t=17.45、t=16.88,P<0.05),早发型组亦低于晚发型组(t=20.22,P<0.05)。结论:子痫前期孕妇血清MMP-9、NGAL水平的上升和胎盘组织MMP-9、NGAL mRNA的表达下降可能通过不同途径共同参与子痫前期的病理生理过程。
Objective: To investigate the changes of MMP-9 and NGAL expression in serum and placenta of pregnant women with preeclampsia. Methods: The clinical data of 100 pregnant women with preeclampsia were retrospectively analyzed. According to the clinical classification, 40 cases were divided into early-onset group and late-onset group. Another 50 cases of normal pregnancy women as control group. Results: The expressions of MMP-9 and NGAL in early-onset and late-onset groups were significantly higher than those in the control group (t = 18.00, t = 19.55, P <0.05) = 10.33, P <0.05). The expressions of MMP-9 mRNA and NGAL mRNA in placenta of early-onset group and late-onset group were lower than those in the control group (t = 17.45, t = 16.88, P <0.05) , P <0.05). Conclusion: The increase of MMP-9 and NGAL in pregnant women with preeclampsia and the decrease of the expression of MMP-9 and NGAL mRNA in placenta may play a role in the pathophysiological process of preeclampsia through different ways.