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蒿甲醚（Ａｒｔ）系青蒿素的衍生物，不仅有抗疟作用，还有抗血吸虫（特别是ｄ７童虫）作用。本文应用Ａｒｔ的早期治疗方案，观察其控制血吸虫感染的可能性。结果表明小鼠于感染日本血吸虫尾蚴当天（ｄｏ）ｉｇＡｒｔ３００ｍｇ．ｋｇ－１，然后每隔２－３ｗｋｉｇ１次相同剂量的Ａｒｔ时，减虫率和减雌虫率均低。若于感染后ｄ７开始ｉｇ首剂Ａｒｔ，然后每ｗｋｉｇ１次，共给４次时，可使宿主体内的雌虫减少近９０％或９０％以上，且部分鼠的雌虫被完全消灭，肝脏亦无明显变化。此外，ｄ７童虫经Ａｒｔ３００ｍｇ·ｋｇ－１作用后，残留的雌虫发育缓慢，治后３ｗｋ（即感染后２８ｄ），大部分雌虫的生殖腺尚未发育成熟，少数虽已发育，但其子宫内的虫卵数较对照组的减少９１．７％。表明Ａｒｔ用于感染血吸虫尾蚴后早期治疗，可起到保护宿主的作用，不仅可控制血吸虫感染，而且还可减轻感染度。
Artemisinin (artemisinin) Artemisinin derivatives, not only have anti-malarial effects, but also the role of anti-schistosomes (especially d7 squirrels). In this paper, Art early treatment program, to observe the possibility of control of schistosomiasis. The results showed that the mice in infected with Schistosoma japonicum cercariae day (do) igArt300mg. kg-1, and then the worm reduction rate and the feminization reduction rate were all low at the same dose of Art1 every 2-3 wkig. If the first dose of Art at the start of d7 after infection, Art, and then wkig1 times, a total of 4 times, the host can reduce the female body nearly 90% or 90% or more, and part of the female rats were completely eliminated, the liver is also No significant changes. In addition, after the d7 siblings were treated with Art 300mg · kg-1, the residual females developed slowly. After 3 weeks of treatment (ie, 28 days after infection), most of the females’ gonads had not yet matured. Although a few had developed, Of the number of eggs than the control group decreased 91.7%. Art shows that for the early treatment of Schistosoma japonicum cercariae, it can play a role in host protection, not only controlling schistosomiasis infection but also reducing the infection rate.