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目的探讨泻热化痰法对急性脑梗死痰热证的血清可溶性细胞黏附分子1(sICAM-1)、血清白介素6(IL-6)水平的影响。方法 60例急性脑梗死痰热证患者,按照随机数字表法分为治疗组和对照组,各30例。对照组患者予以基础治疗,治疗组在对照组基础上联合应用泻热化痰法治疗,观测两组治疗前后血清sICAM-1、IL-6水平变化。结果治疗组治疗后第1、5天sICAM-1浓度分别为(361.36±78.80)、(266.70±51.49)ng/ml,IL-6浓度分别为(19.50±5.01)、(12.67±2.90)ng/ml,均低于对照组,差异有统计学意义(P<0.05)。结论泻热化痰法对痰热证急性脑梗死患者具有良好的治疗效果,进一步丰富了泻热化痰方治疗急性脑梗死痰热证的作用机制。
Objective To investigate the effects of Xierehenhuatan on serum soluble intercellular adhesion molecule-1 (sICAM-1) and serum interleukin-6 (IL-6) levels in patients with phlegm-heat syndrome of acute cerebral infarction. Methods Sixty patients with phlegm-heat syndrome of acute cerebral infarction were divided into treatment group and control group according to random number table method, with 30 cases in each. The patients in the control group were given basic treatment. The treatment group was treated with the method of excreting phlegm and eliminating phlegm on the basis of the control group. The changes of serum sICAM-1 and IL-6 levels in both groups before and after treatment were observed. Results The sICAM-1 concentrations in the treatment group were (361.36 ± 78.80) and (266.70 ± 51.49) ng / ml on the 1st and 5th day after treatment, respectively. The concentrations of IL-6 in the treatment group were (19.50 ± 5.01) and (12.67 ± 2.90) ml, both lower than the control group, the difference was statistically significant (P <0.05). Conclusion Xiehuayuputan has a good therapeutic effect on patients with phlegm-heat syndrome of acute cerebral infarction and further enriches the mechanism of Xiere Huatan Fang in treating phlegm-heat syndrome of acute cerebral infarction.