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以可溶性淀粉原料,K2S2O8-NaHSO3为引发体系,N,N′-亚甲基双丙烯酰胺为交联剂,合成淀粉/N,N′-亚甲基双丙烯酰胺交联微球,采用人工肠液对所得微球进行体外降解,用FT-IR对其结构进行表征,用XRD、TGA对其物性进行分析,用SEM观察了微球及降解8h的产物。结果表明,使用该方法制备的交联微球球型元整,表面粗糙多孔,粒径约25μm,与可溶性淀粉相比结晶度降低,热稳定性提高。降解实验表明,可溶性淀粉在人工肠液中3h内基本降解,而微球经8h降解,仍可稳定维持其交联结构,其降解率为36.58%。因此有望将其作为靶向制剂的药物载体在鼻腔给药系统、动脉栓塞技术、放射性治疗、免疫分析等领域得到广泛应用。
The starch / N, N’-methylenebisacrylamide crosslinked microspheres were synthesized by using soluble starch, K2S2O8-NaHSO3 as initiator and N, N’-methylenebisacrylamide as crosslinking agent. The obtained microspheres were degraded in vitro and their structures were characterized by FT-IR. Their physical properties were analyzed by XRD and TGA. The microspheres and products degraded for 8h were observed by SEM. The results show that the cross-linked microsphere prepared by this method has a rough surface and a porous surface with a diameter of about 25 μm. The crystallinity of the crosslinked microsphere is lower than that of the soluble starch, and the thermal stability is improved. Degradation experiments showed that the soluble starch degraded basically within 3 h in artificial intestinal juice, while the microspheres degraded after 8 h, and the crosslinked structure could still be maintained stably. The degradation rate was 36.58%. Therefore, it is expected to be widely used in the fields of nasal delivery system, arterial embolization, radiotherapy, immunoassay and the like as a drug carrier for targeted preparation.