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浆细胞膜糖蛋白 1 (PC 1 )属 2型膜结合糖蛋白 ,分布于体内多种细胞上。在胰岛素抵抗或 2型糖尿病的人或动物中均发现PC 1的含量增高伴胰岛素受体酪氨酸激酶活性的下降及自动磷酸化作用的降低 ,从而抑制了胰岛素的作用 ,导致胰岛素抵抗。其抑制作用位点可能位于受体或受体后。部分实验证实PC 1对胰岛素的抑制作用与PC 1基因突变或多态性有关 ,提示可通过应用PC 1的单克隆抗体或二甲双胍来降低PC 1含量或阻碍PC 1与胰岛素受体相互作用 ,治疗部分胰岛素抵抗的病人。
Plasma membrane glycoprotein 1 (PC 1) is a type 2 membrane-bound glycoprotein that is found in many cells in the body. In either insulin resistance or type 2 diabetes, both increased levels of PC1 and decreased insulin receptor tyrosine kinase activity and autophosphorylation have been found in either human or animals with insulin resistance or type 2 diabetes, thereby inhibiting insulin action and leading to insulin resistance. Its inhibitory site may be located in the receptor or receptor. Some experiments confirmed that the inhibitory effect of PC 1 on insulin and PC 1 gene mutation or polymorphism, suggesting that by using PC 1 monoclonal antibody or metformin to reduce the PC 1 content or hinder the PC 1 and insulin receptor interaction, treatment Partial insulin resistance in patients.