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公元前古希腊罗马学者就发现伴随铅绞痛有肌肉麻痹。到1839年法国人Taquerel des Planches曾详细地描述过铅中毒引起末梢神经障碍的体征。此后从1944年Cantarow和Trumper就开始采纳了Dejerine-klumpke(1899)的肌肉麻痹分类法,此法将肌肉麻痹分为前臂型、上臂型、阿-杜二氏病型、腓骨型和喉头肌型五类麻痹,以后此法就长期沿用下来了。 1880年Gombanlt进行豚鼠试验,证实铅可引起末梢神经纤维节段性脱髓鞘。以后大家又针对铅引起的末梢种经组织变化是雪旺氏细胞还是轴索障碍,是神经纤维内膜的神经内膜血管障碍还是脊髓前角细胞障碍等问题,继续在光学显微镜以致电子显微镜的水平上进行着实验研究,直至现今。另一方面,Hodes、(1948)Dawson和Scott
Ancient Greek and Roman scholar BC found muscle paralysis associated with lead colic. By 1839 French Taquerel des Planches had described in detail the signs of lead poisoning caused by peripheral nerve disorders. Since then Cantarow and Trumper have adopted the Muscle Paralysis Taxonomy of Dejerine-klumpke (1899) in 1944, which divides muscular paralysis into forearm, upper arm, Adduard’s disease, fibula and laryngeal muscle Five paralysis, after the law on the long-term use down. In 1880 Gombanlt guinea pig experiments, confirmed lead can cause peripheral nerve fiber segmental demyelination. Later, we also aimed at lead-induced changes in peripheral tissue is Schwann cells or axonal disorders, is the nerve fibers of the intima or endometrial vascular endoplasmic dysfunction problems such as spinal cord anterior horn, and continue in the optical microscope so that electron microscopy At the level of experimental research, until now. On the other hand, Hodes, (1948) Dawson and Scott