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目的观察血清肿瘤标志物鳞状细胞癌相关抗原(SCC)、糖类抗原(CA)125、CA19-9在人乳头瘤病毒(HPV)感染者中水平的变化及其临床意义。方法收集经HPV DNA确诊的HPV感染者217例,其中高危型组130例,低危型组87例,采用化学发光法分别测定血清SCC、CA125、CA19-9的水平,以80例HPV阴性者作对照。正态分布的计量资料采用x珋±s表示,进行方差分析及两两比较的LSD-t检验;非正态分布的计量资料采用中位数(最小值,最大值)表示,进行秩和检验。结果高危型组血清SCC、CA125、CA19-9的浓度分别为1.7(0.8,189.0)μg/L、(58.51±35.73)U/ml、21.11(14.98,83.80)U/ml,低危型组为1.8(1.0,74.0)μg/L、(30.45±25.69)U/ml、13.66(8.35,80.90)U/ml,均高于对照组的1.7(0.6,18.6)μg/L、(20.11±15.18)U/ml、7.36(5.64,12.76)U/ml,差异有统计学意义(P均<0.05);且高危组三项指标也高于低危组(P均<0.05)。HPV感染与血清SCC、CA125及CA19-9水平三者之间呈正相关(r=0.3152、0.5111、0.4862)。结论 HPV感染可致血清SCC、CA125、CA19-9水平升高,结合临床症状综合分析,有利于宫颈病变的辅助诊断及病情估计。
Objective To observe the changes of serum tumor markers SCC, CA125 and CA19-9 in human papillomavirus (HPV) infection and its clinical significance. Methods A total of 217 cases of HPV infection confirmed by HPV DNA were collected, including 130 cases in high-risk group and 87 cases in low-risk group. The serum levels of SCC, CA125 and CA19-9 were determined by chemiluminescence method. As a control. Normal distribution of measurement data using x 珋 ± s said analysis of variance and pairwise comparison LSD-t test; non-normal distribution of measurement data using the median (minimum, maximum) that the rank sum test . Results The serum levels of SCC, CA125 and CA19-9 in high risk group were 1.7 (0.8189.0) μg / L, 58.51 ± 35.73 U / ml and 21.11 (14.98, 83.80) U / 1.8 (1.0,74.0) μg / L, (30.45 ± 25.69) U / ml and 13.66 (8.35,80.90) U / ml were significantly higher than those in the control group U / ml, 7.36 (5.64,12.76) U / ml, the difference was statistically significant (P all <0.05); and high risk group of three indicators are also higher than the low risk group (P all <0.05). HPV infection and serum SCC, CA125 and CA19-9 levels were positively correlated between the three (r = 0.3152,0.5111,0.4862). Conclusion HPV infection can cause the serum levels of SCC, CA125 and CA19-9 to increase. Combined with the comprehensive analysis of clinical symptoms, it is helpful for the diagnosis and prognosis of cervical lesions.