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目的:探讨降低体质量指数(BMI)对多囊卵巢综合征(PCOS)患者妊娠结局和新生儿结局的影响。方法:选取于2015年1月至2015年12月广东省中山市博爱医院就诊的妊娠前BMI≥23.0 kg·m-2的PCOS患者338例,根据治疗后BMI是否降低分组,研究组为经过治疗BMI下降的PCOS患者;对照组为BMI未下降的PCOS患者,评价两组患者妊娠结局及新生儿结局等情况。结果:治疗前两组BMI、卵泡刺激素(FSH)、黄体生成素(LH)、睾酮(T)、性激素结合球蛋白(SHBG)、空腹葡萄糖(GLU)、空腹胰岛素(INS)的表达水平比较,差异均无统计学意义(P>0.05),治疗后研究组患者上述指标的检测结果均优于对照组患者,差异具有统计学意义(P<0.05)。研究组妊娠率65.79%高于对照组的47.97%,妊娠期糖尿病、妊娠期高血压疾病的发生率显著低于对照组体质量组,差异具有统计学意义(P<0.05);早产儿的发生率也显著降低,差异具有统计学意义(P<0.05)。结论:孕前降低BMI的PCOS患者能够提高妊娠几率,发生妊娠期并发症及新生儿不良结局的风险减低,故对BMI过高的这类患者应加强体质量的控制,进行有效的系统健康管理,以期改善母婴结局。
Objective: To investigate the effect of lowering body mass index (BMI) on pregnancy outcome and neonatal outcome in women with polycystic ovary syndrome (PCOS). METHODS: A total of 338 PCOS patients with pre-pregnancy BMI≥23.0 kg · m-2 who were treated at Pok Oi Hospital of Zhongshan City, Guangdong Province from January 2015 to December 2015 were selected. According to whether the BMI decreased after treatment, the study group was treated BMI decreased PCOS patients; control group was not decreased in BMI PCOS patients, evaluation of both groups of patients with pregnancy outcomes and neonatal outcomes and so on. Results: The levels of BMI, follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), sex hormone binding globulin (SHBG), fasting glucose (GLU) and fasting insulin (INS) , There was no significant difference (P> 0.05). After treatment, the test results of the above indexes in the study group were better than those in the control group, the difference was statistically significant (P <0.05). The pregnancy rate of study group was 65.79% higher than that of control group (47.97%). The incidence of gestational diabetes mellitus and gestational hypertension was significantly lower than that of control group (P <0.05). The incidence of premature infants The rate was also significantly reduced, the difference was statistically significant (P <0.05). CONCLUSIONS: PCOS patients with pre-pregnancy BMI reduction can reduce the risk of pregnancy, complications of pregnancy and risk of neonatal adverse outcomes. Therefore, patients with high BMI should be strengthened in body weight control, effective system health management, With a view to improving the outcome of maternal and child.