【摘 要】
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Background Transforming growth factor-beta (TGF-β) and matrix metalloproteinases-9 (MMP-9) have been implicated in the pathogenesis of human atherosclerosis bu
【机 构】
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Department of Cardiology,Department of Neurology
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Background Transforming growth factor-beta (TGF-β) and matrix metalloproteinases-9 (MMP-9) have been implicated in the pathogenesis of human atherosclerosis but their relationship during lesion progression are poorly understood. The objective of This study was to investigate the expression of MMP-9, TGF-β1 and TGF-β receptor Ⅰ (TβR-Ⅰ) in human atherosclerotic plaque and their relationship and plaque stability.Methods Specimens of human coronary artery atherosclerotic plaques were obtained from 41 patients undergoing coronary endarterectomy, and were paraffin embedded, sectioned at 4 μm intervals then stained with haematoxylin and eosin. They were divided into stable (with no or only little lipid core) and unstable plaque groups (with lipid core size＞40%): the immunohistochemical staining were performed for MMP-9,TGF-β1 and TβR-Ⅰ.Results The expression of MMP-9 in the unstable plaques was much higher than in the stable ones, but the expression of TGF-β1 was higher in the stable plaques. There was no similar significant difference for TβR-Ⅰ. Correlation analysis showed that there was a negative correlation between the expression of MMP-9 and TGF-β1 (r=-0.332, P=0.034 for average areal density; r=-0.373, P= 0.016 for average optical density).Conclusions There were close relationships between MMP-9, TGF-β1 and plaque stability. Enhanced production of MMP-9 may participate in the formation of unstable plaque, while TGF-β1 maybe an important stabilizing factor in preventing transition into an unstable plaque phenotype.
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