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应用LSAB免疫组化及TUNEL技术检测神经母细胞瘤(NB)中bcl-2蛋白表达和细胞凋亡,以探讨bcl-2基因调控作用与细胞凋亡在NB发生发展中的作用.结果表现,17例NB均有bcl-2蛋白表达阳性细胞及凋亡细胞,表达指数(BEI)为9.8％～61.8％,凋亡指数(AI)为2％～16.7％,二者呈负相关。BEI在不同分组间差异无显著性意义,而AI差异有显著性意义,且AI与术后生存时间呈正相关.结果提示:bcl-2基因异常表
The expression of bcl-2 protein and apoptosis in neuroblastoma (NB) were detected by LSAB immunohistochemistry and TUNEL technique to explore the role of bcl-2 gene regulation and apoptosis in the development of NB.Results: The expression of bcl-2 protein positive cells and apoptotic cells were all found in 17 cases of NB. The expression index (BEI) was 9.8% -61.8%, and the apoptosis index (AI) was 2% -16.7%. There was no significant difference in BEI between different groups, but there was a significant difference in AI, and the AI was positively correlated with postoperative survival time.The results suggest that the abnormal expression of bcl-2 gene