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In recent years, considerable efforts have been expended to the development ofenantioselective synthesis of α-amino acids and the use of α-amino acids as chiralbuilding blocks for the synthesis of complex molecules. Numerous unnatural aminoacids which are often the characteristic units of biologically active peptides, have alsobeen discovered. Herein we describe a convenient and general access to natural andunnatural α-amino acids which are based on the use of the chiral building blocks,(S)-1a-e and (R)-1a-e from kinetic resolution of α-furfuryl amines (Scheme 1).
In recent years, considerable efforts have been expended to the development of enantioselective synthesis of α-amino acids and the use of α-amino acids as chiral building blocks for the synthesis of complex molecules. Numerous unnatural aminoacids which are often the characteristic units of biologically active peptides Herein we describe a convenient and general access to natural and natural alpha-amino acids which are based on the use of the chiral building blocks, (S) -1a-e and (R) -1a-e from kinetic resolution of α-furfuryl amines (Scheme 1).