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本文为1982年5～6月在吉林省延边地区和龙县长红林场82公里处某施工部队临时驻地的 HFRS 暴发流行的病原学调查。用免疫荧光法对现场扑获的102只野鼠(其中大林姬鼠57只、棕背(鼠平)16只、花鼠12只、东方田鼠9只、红背鼠、平4只、黑线姬鼠3只、鼠兔1只)进行了 HFRS 相关抗原的检出,其中大林姬鼠阳性21只,带毒率21.1%(12/57);棕背鼠平阳性2只、带毒率为12.5%(2/16)。确定了大林姬鼠、棕背(鼠平)为此次暴发流行的病毒抗原的贮存宿主。在我国首次发现大林姬鼠、棕背(鼠平)携带 HFRS 病毒抗原。为该病的流行病学调查、预防和临床治疗提供了病原依据。可供今后对本病传染源的进一步调查及流行规律观察参考。本文还对 HFRS 病毒抗原在鼠类中寄生的脏器和细胞进行了免疫荧光定位观察,并进行了讨论。
This essay is an epidemiological investigation of the epidemic of HFRS outbreak in a temporary station of a construction unit at 82 km from Longhong Forest Farm, Longyan, Yanbian, Jilin Province, from May to June, 1982. A total of 102 wild rats (57 Apodemus agrarius, 16 Brownback rats, 12 Ratchromosomes, 9 Microtus fortis, 4 red-backed rats, 4 pigs) 3 mice and 1 rabbit) were tested for HFRS-associated antigen, 21 of which (21.1%) were positive for Apodemus agrarius; 2 % (2/16). Determined Apodemus merganser, brown back (mouse flat) for the outbreak of viral antigen storage host. In our country, we found for the first time that Apodemus agrarius and Brownback (rat plague) carry HFRS virus antigens. It provided the etiological basis for the epidemiological investigation, prevention and clinical treatment of the disease. Available for further investigation of the source of the disease in the future and epidemic observation reference. In addition, immunofluorescence localization of organs and cells parasitized by HFRS virus in mice was also discussed and discussed.