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通过免疫组化方法结合计算机图象分析，对４８例颊粘膜鳞癌患者肿瘤内微血管与转移的关系进行了定量研究。结果显示：颊癌内微血管密度明显高于正常人，且随着肿瘤局部淋巴结转移和全身转移的出现，颊癌内微血管密度也增加，当４００倍视野内血管密度超过４５条／ｍｍ２时，１００％的患者发生肿瘤转移。颊癌内微血管密度可以预测转移发生的危险性，指导临床治疗方案的选择。另外，本文对颊癌内血管生成与血道和淋巴道转移可能的机理进行了初步分析。
48 cases of buccal mucosal squamous cell carcinoma by immunohistochemistry combined with computer image analysis of the relationship between microvascular and metastasis were studied quantitatively. The results showed that the microvessel density in buccal carcinoma was significantly higher than that in normal people, and with the occurrence of local lymph node metastasis and systemic metastasis, the microvessel density in buccal carcinoma also increased. When the vascular density in 400 times visual field exceeded 45 / mm2 Tumor metastasis occurred in% of patients. Microvessel density in the buccal carcinoma can predict the risk of metastasis and guide the choice of clinical treatment options. In addition, a preliminary analysis of the possible mechanisms of angiogenesis and hematogenous and lymphatic metastasis in buccal carcinoma was performed.