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目的 了解2型DM患者的抑郁焦虑状况和选择性5 -羟色胺回收抑制剂百忧解干预治疗的效果。方法 用抑郁自评量表 (SDS)和焦虑自评量表 (SAS)对76例2型DM进行抑郁焦虑状况的评价 ,同时对SDS和 (或 )SAS积分大于41的患者进行单盲对照 ,12例用百忧解治疗3个月。结果 2型DM患者SDS、SAS评分与我国常模比较明显增高 (p<0.01) ;经3个月的百忧解治疗 ,使用百忧解的患者SDS和SAS评分较安慰剂明显改善 (p<0.05) ,血糖代谢亦有好转 (p<0.05)。结论 2型DM患者存在情绪障碍 ,而百忧解使患者的焦虑和抑郁症状得到改善 ,并有利于糖尿病病情的控制。
Objective To investigate the status of depression and anxiety in patients with type 2 DM and the effect of Prozac, a selective inhibitor of 5-hydroxytryptamine. Methods 76 patients with type 2 DM were evaluated for depression and anxiety using Self-rating Depression Scale (SDS) and Self-rating Anxiety Scale (SAS), and single-blind control was performed on patients with SDS and / or SAS score greater than 41, 12 cases treated with Prozac for 3 months. Results The SDS and SAS scores of type 2 DM patients were significantly higher than those of normotensive subjects in China (p <0.01). SDS and SAS scores of patients treated with Prozac after 3 months treatment were significantly improved compared with placebo (p < 0.05), blood glucose metabolism also improved (p <0.05). Conclusions There are mood disorders in type 2 DM patients, and Prozac caused anxiety and depression symptoms to be improved, which is also beneficial to the control of diabetes.