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目的本研究旨在探讨一氧化氮(NO)和血管内皮生长因子(VEGF)在溃疡性结肠炎(UC)发生发展中的关系。方法根据UC患者病情程度分为活动组(n=44)和缓解组(n=16),并以健康查体者编成对照组(n=20)。取清晨空腹血液以检测其内VEGF、NO及白细胞(WBC)、血小板(PLT)的含量。结果UC活动组中血液的VEGF、NO均明显高于缓解组(P<0.001)和对照组(P<0.001),而缓解组与对照组间无统计学差异(P>0.05)。在活动组中,VEGF与NO存在正相关性(r=0.48,P<0.01),而在对照组中则无相关性(r=0.179,P>0.05)。另外,在活动组中,WBC计数超出正常参考值范围的患者只占22.7%,而PLT也仅占31.8%。但总体而言,活动组血液中WBC、PLT与对照组及缓解组相比,均有统计学差异(P<0.001或P<0.01)。结论在UC疾病的发生发展中,VEGF与NO可能有协同作用。
Objective To investigate the relationship between nitric oxide (NO) and vascular endothelial growth factor (VEGF) in the development of ulcerative colitis (UC). Methods According to the severity of UC patients, the patients were divided into active group (n = 44) and remission group (n = 16), and healthy controls were enrolled as control group (n = 20). Fetal morning fasting blood to detect its VEGF, NO and white blood cells (WBC), platelet (PLT) content. Results The levels of VEGF and NO in the UC group were significantly higher than those in the remission group and the control group (P <0.001). However, there was no significant difference between the remission group and the control group (P> 0.05). There was a positive correlation between VEGF and NO in the active group (r = 0.48, P <0.01), but not in the control group (r = 0.179, P> 0.05). In addition, only 22.7% of patients in the active group had WBC count exceeded the normal reference range, while PLT accounted for only 31.8%. Overall, however, there was a significant difference (P <0.001 or P <0.01) between WBC and PLT in the active group compared with the control and remission groups. Conclusion In the development of UC disease, VEGF and NO may have a synergistic effect.