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目的 :探讨具有高危感染因素的肝硬化并上消化道出血后感染患者的预防性抗生素应用价值。方法 :收集 86例患者分组观察 ,观察组在止血治疗的基础上给予头孢氨噻肟钠 2 0Did 7d预防性治疗 ;对照组不用抗生素。结果 :观察组 46例继发感染 12例 (2 6 0 8% ) ,而对照组 40例继发感染 2 1例 (5 2 5 % ) (P <0 0 0 5 ) ;死亡率观察组死亡 8例 (17 40 % ) ,对照组死亡 14例 (35 % ) (P <0 0 5 )。结论 :早期 ,规则预防性抗生素治疗具有高危感染因素的肝硬化上消化道出血患者能降低其感染发生率和死亡率。
Objective: To investigate the value of prophylactic antibiotics in patients with cirrhosis and upper gastrointestinal bleeding after high-risk infection. Methods: A total of 86 patients were divided into groups. The observation group was given cefotaxime sodium 20Did 7d on the basis of hemostasis. The control group did not use antibiotics. Results: In the observation group, 12 cases (26.0%) had secondary infection, while 40 cases in the control group had 21 cases (525%) of secondary infection (P <0.05). The death rate observation group died 8 cases (17 40%), and 14 cases (35%) died in the control group (P <0 05). CONCLUSIONS: Early, regular prophylactic antibiotics in patients with cirrhosis and upper gastrointestinal bleeding who are at high risk of infection can reduce their incidence of infection and mortality.