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目的探讨腹部间质瘤(abdominal stromal tumors,AST)的临床病理特点及诊治方法。方法对40例AST患者的临床资料进行回顾性分析。结果40例AST患者发生部位以胃(18例,45.0%)和小肠(8例,20.0%)为主。主要临床表现为腹痛、腹胀(29例,72.5%),消化道出血(13例,32.5%),腹部包块(12例,30.0%)和消化道梗阻(10例,25.0%)。免疫组化CD117阳性37例(92.5%),CD34阳性33例(82.5%),同时表达CD117和CD34者30例(75.0%),无CD117与CD34均阴性者。全部患者均行手术治疗。结论AST是消化道最常见的间叶源性肿瘤。CD117和CD34阳性可作为AST的诊断标准。外科手术与分子靶向药物的结合将是GIST的主要治疗模式。
Objective To investigate the clinicopathological features and diagnosis and treatment of abdominal stromal tumors (AST). Methods The clinical data of 40 patients with AST were retrospectively analyzed. Results The location of 40 patients with AST was mainly stomach (18 cases, 45.0%) and small intestine (8 cases, 20.0%). The main clinical manifestations were abdominal pain, bloating (29 cases, 72.5%), gastrointestinal bleeding (13 cases, 32.5%), abdominal mass (12 cases, 30.0%) and gastrointestinal obstruction (10 cases, 25.0%). There were 37 cases (92.5%) positive for CD117, 33 (82.5%) positive for CD34, 30 cases (75.0%) for CD117 and CD34, but no negative for CD117 and CD34. All patients underwent surgical treatment. Conclusion AST is the most common mesenchymal tumor in the digestive tract. CD117 and CD34 positive can be used as a diagnostic criteria for AST. The combination of surgery and molecularly targeted drugs will be the primary treatment modality for GIST.