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虽然人体实体瘤的细胞遗传学研究己发现妇科肿瘤一些类型中核型畸变特点,如子宫平滑肌瘤的t(12;14)(q14-15;q23-24);子宫颈癌和子宫内膜腺癌中1号染色体重排和1三体;乳腺癌中1号染色体畸变或涉及16q缺失等,但是卵巢生殖细胞索及生殖细胞基质肿瘤的研究数据仍不多。作者首次报道一例仅以12三体为唯一染色体畸变的泡膜细胞瘤患者。患者69岁,因有3周阴道出血和右下腹痛于1987年5月就诊。妇科检查及超声波检查,发现直肠子宫陷凹的右侧有一个大约13×10×6cm的多环肿瘤,双侧输卵管卵巢
Although cytogenetic studies of human solid tumors have revealed karyotypic aberrations in some types of gynecologic tumors, such as uterine leiomyomas t(12;14)(q14-15;q23-24); cervical cancer and endometrial glands Chromosome 1 rearrangements and trisomy 1 in cancer; aberrations in chromosome 1 or 16q deletion in breast cancer, but the data on ovarian germline and germ cell stromal tumors is still relatively small. The authors reported for the first time a case of a patient with capsular cell tumor with only 12 trisomy as the only chromosomal aberration. The patient was 69 years old and presented in May 1987 with 3 weeks of vaginal bleeding and right lower abdominal pain. Gynecological examination and ultrasound examination found that there is a polycyclic tumor of approximately 13×10×6 cm on the right side of the rectal uterine cavity, bilateral oviductal ovaries