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目的探讨二甲双胍联合复方醋酸环丙孕酮对多囊卵巢综合征(PCOS)患者糖脂代谢及激素水平的影响。方法选取2016年3—11月沈阳市第七人民医院收治的70例PCOS患者作为研究对象,采用随机数字表法将其分为对照组与试验组,每组35例。对照组患者给予复方醋酸环丙孕酮,试验组则采用二甲双胍联合复方醋酸环丙孕酮进行治疗,比较两组患者临床疗效、治疗前后糖脂代谢变化及激素水平。结果试验组患者治疗的总有效率为82.9%,明显高于对照组的68.6%,差异有统计学意义(P<0.05);治疗后,试验组患者的空腹血糖(FBG)、三酰甘油(TG)和总胆固醇(TC)水平均明显低于对照组,差异均有统计学意义(均P<0.05);治疗后,试验组患者的促卵泡激素(FSH)、黄体生成素(LH)、睾酮(T)水平均明显低于对照组,差异均有统计学意义(均P<0.05)。结论二甲双胍联合复方醋酸环丙孕酮治疗PCOS临床效果显著,可有效降低患者激素水平,改善糖脂代谢。
Objective To investigate the effects of metformin combined with cyproterone acetate on glucose and lipid metabolism and hormone levels in patients with polycystic ovary syndrome (PCOS). Methods Seventy patients with PCOS who were admitted to Shenyang Seventh People’s Hospital from March to November in 2016 were selected as the research object. They were divided into control group and experimental group by random number table method, with 35 cases in each group. Patients in the control group were given compound cyproterone acetate. Patients in the test group were treated with metformin plus cyproterone acetate. The clinical curative effect, the changes of glycolipid metabolism and the hormone levels before and after treatment were compared between the two groups. Results The total effective rate of treatment group was 82.9%, which was significantly higher than that of control group (68.6%, P <0.05). After treatment, the fasting blood glucose (FBG), triglyceride TG and TC were significantly lower than those in the control group (all P <0.05). After treatment, the levels of FSH, LH, Testosterone (T) levels were significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusion Metformin combined with cyproterone acetate in the treatment of PCOS has a significant clinical effect, which can effectively reduce hormone levels and improve glucose and lipid metabolism.