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目的 了解江苏省艾滋病病毒 (HIV)感染的流行特征、传染来源及危险因素 ,推断其流行趋势 ,为制定防制策略提供依据。方法 使用酶联免疫吸附法及免疫印迹试验对高危人群进行HIV抗体检测 ,采集感染者全血分离淋巴细胞用套式聚合酶链反应扩增HIV - 1DNA片段进行序列分析 ,鉴定病毒亚型。结果 从 1986年至 2 0 0 1年 6月底 ,全省共监测各类人群 95 4 4 4 5人次 ,发现HIV抗体阳性者 133例 ,检出率为 0 14‰ ,其中艾滋病病人 (AIDS) 8例 ,死亡 4例。对 19例HIV感染者进行了亚型鉴定 ,HIV - 1M群共有 4种亚型。A ,B′ ,C ,D。献血员中 85 71%为B′亚型 ,吸毒人群均为C亚型 ,回国劳务人员为A和D亚型。结论 江苏省艾滋病病毒感染的流行已进入快速增长期 ,以静脉吸毒和性途径传播为主 ,HIV - 1毒株亚型复杂 ,防治工作形势严峻。应尽快开展性病艾滋病的综合监测和高危人群的行为干预
Objective To understand the epidemiological characteristics, sources of infection and risk factors of HIV infection in Jiangsu Province, infer its epidemic trend and provide basis for the development of control strategy. Methods HIV antibody was detected in high risk population by enzyme - linked immunosorbent assay (ELISA) and Western blotting. HIV - 1 DNA fragments were amplified by nested polymerase chain reaction (PCR) and sequenced. The virus subtypes were identified. Results From 1986 to the end of June 2001, a total of 95,444 people of all kinds were monitored in the province. 133 HIV-positive cases were detected, with a detection rate of 0 14%, of which AIDS 8 Cases, 4 patients died. The subtypes of 19 HIV - infected individuals were identified. There are 4 subtypes of HIV - 1M cohorts. A, B ’, C, D. 85 71% of blood donors are B ’subtype, drug addicts are C subtype, and returning service workers are A and D subtypes. Conclusions The prevalence of HIV infection in Jiangsu Province has entered a period of rapid increase. The drug is mainly transmitted by intravenous drug use and sexually transmitted diseases. The subtypes of HIV - 1 strains are complicated and the prevention and treatment work is in dire situation. As soon as possible to carry out comprehensive monitoring of STD and AIDS and behavioral interventions for high-risk groups