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盐酸米托蒽醌(ｍｉｔｏｘａｎｔｒｏｎｅｈｙｄｒｏｃｈｌｏｒｉｄｅ,ＭＴＺ）是一种为克服阿霉素心脏毒性反应而开发的新一代蒽环类抗癌药物。该药能抑制ＤＮＡ和ＲＮＡ合成,与碱基强有力的结合嵌入ＤＮＡ,引起ＤＮＡ链间和链内交叉连结,导致单链和双链断裂并抑制ＲＮＡ聚合酶
Mitoxantrone hydrochloride (MTZ) is a new generation of anthracycline anticancer drugs developed to overcome the cardiotoxicity of doxorubicin. The drug can inhibit the synthesis of DNA and RNA, a strong base with DNA embedded, causing inter-and inter-chain cross-linked DNA, resulting in single-and double-strand breaks and inhibit RNA polymerase