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目的:探讨细胞色素P4502E1(CYP2E1)基因多态性与胃腺癌易感性的关系,为胃癌高危人群的筛选和预防控制工作提供科学依据。方法:选择41例胃腺癌患者(胃癌组)及41例健康对照者(对照组),分别采用PCR-RFLP技术与多重PCR方法,检测CYP2E1基因型,观察其多态性,然后进行统计学分析。结果:CYP2E1C1/C1基因型(纯合子野生型)在胃癌组和对照组中的分布频率分别是61.0%和41.5%,差异具有显著性(χ2=6.71,P<0.05)。结论:CYP2E1C1/C1基因型与胃癌遗传易感性相关。
Objective: To investigate the relationship between the polymorphism of cytochrome P4502E1 (CYP2E1) and susceptibility to gastric adenocarcinoma and to provide a scientific basis for the screening and prevention and control of high-risk gastric cancer. Methods: Forty-one patients with gastric adenocarcinoma (gastric cancer group) and 41 healthy controls (control group) were enrolled. The genotypes of CYP2E1 were detected by PCR-RFLP and multiplex PCR respectively. The polymorphism of CYP2E1 was observed and then analyzed statistically . Results: The frequencies of CYP2E1C1 / C1 genotype (homozygous wild type) in gastric cancer group and control group were 61.0% and 41.5%, respectively. The difference was significant (χ2 = 6.71, P <0.05). Conclusion: CYP2E1C1 / C1 genotype is associated with genetic susceptibility to gastric cancer.