论文部分内容阅读
牙周炎是成年人牙齿丧失的首位原因,如何使破坏的牙周组织再生是人们关注的焦点。植骨术、引导性组织再生技术(GTR)、生长因子应用等是目前研究较多的牙周组织再生技术,其中植骨术和GTR虽然在临床实践中已广泛应用,但其临床适应证范围有限,治疗效果并非完全理想,只能获得有限的牙周组织再生。干细胞移植是组织工程技术的一部分,从提出至今一直备受关注,已有研究证实干细胞移植可促进牙周组织再生,但是干细胞移植也存在很多困难和风险,如干细胞的获得途径少,体外扩增中干细胞的功能(增殖,分化,归巢,迁移能力)可能降低,干细胞体外培养或移植过程中外界病原菌的感染、供受宿主之间的免疫反应等。自体再生技术可以弥补以上的缺点,因此已成为当前国际牙周
Periodontitis is the first cause of tooth loss in adults. How to regenerate damaged periodontal tissue is the focus of attention. Bone grafting, guided tissue regeneration (GTR), application of growth factor and so on are the most commonly studied periodontal tissue regeneration techniques. Although bone grafting and GTR have been widely used in clinical practice, the scope of clinical indications Limited, the therapeutic effect is not completely ideal, only limited access to periodontal tissue regeneration. Stem cell transplantation has been a part of tissue engineering and has been receiving much attention since it was proposed. Stem cell transplantation has been reported to promote periodontal tissue regeneration, but there are also many difficulties and risks associated with stem cell transplantation, such as stem cell acquisition, in vitro expansion Stem cells in the function (proliferation, differentiation, homing, migration ability) may be reduced, stem cells in vitro culture or transplantation pathogenic bacteria infection, for the host immune response. Autologous regeneration technology can make up for the above shortcomings, it has become the current international periodontal