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目的 :探讨中药针剂葛根素加脉安定早期静滴防治急性心肌梗死 (AMI)再灌注损伤的效果。方法 :对 10 2例AMI患者随机分为试验组和对照组 ,每组 51例 ;试验组采用葛根素加脉安定 ,对照组用极化液 ;溶栓和其他治疗两组均常规进行。结果 :两组HR、mBP无明显差异 ,试验组O2 max、RA显著减少 (P <0 .0 5和P <0 .0 1) ;CK、CK MB和HBD峰值显著低于对照组 ,且降至正常值的时间明显缩短 (P <0 .0 1) ;WBC平均总数和中性平均百分比在 4 8h～ 5d试验组显著降低 (P <0 .0 5) ;BUN、Cr治疗前后试验组差异有显著性 (P <0 .0 5) ,对照组差异无显著性 ;MIER为 7.8% ,其中试验组为 5.9% ,对照组 9.8%。综合疗效评价试验组达 96.1% ,对照组为 82 .4 % (P <0 .0 1)。结论 :葛根素加脉安定对急性心梗再灌注损伤有明显的防治效果。
Objective: To investigate the effect of traditional Chinese medicine injection of puerarin and verapamil on early intravenous infusion to prevent and cure acute myocardial infarction (AMI) reperfusion injury. Methods: A total of 102 cases of AMI were randomly divided into test group and control group, with 51 cases in each group. Puerarin plus verapamil was used in the experimental group, while the control group was treated with polar liquid. Thrombolytic therapy and other treatments were routinely performed in both groups. Results: There was no significant difference between the two groups in HR and mBP. The levels of O2 max and RA in the experimental group were significantly decreased (P <0.05 and P <0.01); the peak values of CK, CK MB and HBD were significantly lower than those in the control group (P <0.01). The average total number of WBC and the average percentage of neutrality were significantly decreased in 48 h ~ 5 d experimental group (P <0.05). The difference of experimental group before and after BUN and Cr treatment (P <0.05), while there was no significant difference in the control group. The MIER was 7.8%, which was 5.9% in the test group and 9.8% in the control group. The comprehensive efficacy evaluation test group reached 96.1%, while the control group was 82.4% (P <0.01). Conclusion: Puerarin plus verapamil has obvious preventive and therapeutic effects on acute myocardial infarction reperfusion injury.