Delayed release particles from vascular endothelial growth factor for repairing spinal cord ischemic

• 作 者: CHEN Yang LI Feng XIAO Jian-de LI Zhen-yu YANG Lei LUO Xin-le
• 机 构: Department of Orthopaedics,Shenzhen Second People's Hospital
• 出 处: 中华创伤杂志英文版
• 发表日期: 2007年10期
• 关键词: Vascular endothelial growth factors Spinal cord Ischemia

Objective:To study the effect of delayed release particles from vascular endothelial growth factor (VEGF)on the reparation of ischemic injury of spinal cord in rats. Methods:The spinal cord ischemia model of rats was established.The delayed release particles from VEGF were injected via the intubation of spinal subarachnoid space.The rehabilitation was observed by the assessment of unfold claw reflection,space between toes,spinal evoked potential (SEP) and motor evoked potential (MEP). Results:VEGF prompted SEP and MEP appearance,improved the motor function of hind limbs. Conclusions:VEGF can promote the rehabilitation of spinal cord ischemic injury of rats.