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试用铝导致小鼠急性脑铝中毒，制作痴呆模型。小鼠脑室埋管，分别注射０１２５％、０２５％、０５％ＡｌＣｌ３，每只２μｌ／ｄ，连续５ｄ，２０ｄ后小鼠在跳台法和避暗法实验中，潜伏期明显缩短错误数明显增多，且随着脑室注射ＡｌＣｌ３浓度的升高，潜伏期逐渐缩短，错误数逐渐增多，有明显的量效关系。结果表明，小鼠脑室埋管多次注射ＡｌＣｌ３后，可致急性脑铝中毒，出现学习记忆功能障碍，可作为一种急性痴呆动物模型供实验用
Trial aluminum lead to acute cerebral aluminum poisoning in mice, making dementia model. The mice were injected with 0.1%, 0.25% and 0.5% AlCl3 into the ventricles of the mice respectively, and the incubation period was significantly shortened in both the step-down method and the dark-avoidance method The number of errors increased significantly, and with the increase of intracerebroventricular injection of AlCl3, the incubation period gradually shortened, the number of errors gradually increased, with a significant dose-response relationship. The results showed that the multiple injection of AlCl3 into the ventricle of the mouse brain could cause acute cerebral aluminum poisoning and learning and memory dysfunction, which could be used as an experimental animal model of acute dementia