论文部分内容阅读
目的 分析血清甘胆酸(CG)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆汁酸(TBA)、总胆红素(TBIL)测定对新疆维吾尔族妊娠期肝内胆汁淤积症(ICP)的诊断价值及意义.方法 采用化学发光法检测血清甘胆酸浓度、乳酸脱氢酶法测定谷丙转氨酶、采用苹果酸脱氢酶法测定谷草转氨酶、采用循环酶法检测的总胆汁酸浓度、采用钒酸盐氧化法测定血清总胆红素.结果 妊娠期肝内胆汁淤积症维吾尔族患者的血清甘胆酸、谷丙转氨酶、谷草转氨酶、总胆汁酸、总胆红素测定结果均显著高于正常对照组,差异具有统计学意义(P＜0.01).通过对不同分组围产儿结局比较,ICP组产妇早产、羊水胎粪污染、新生儿窒息、胎儿窘迫发生率分别为25％、36.538％、15.385％、44.231％,均高于正常对照组的健康人群,差异具有统计学意义(P＜0.05).结论 血清肝胆酸、谷丙转氨酶、谷草转氨酶、总胆汁酸、总胆红素的测定对妊娠期肝内胆汁淤积症的诊断是密切相关的,同时监测上述指标对于诊疗ICP患者,保护母婴健康具有重要意义.“,”Objective:Analysis of serum cholyglycine (CG),alanine transaminase (ALT),glutamic-oxalacetic transaminase (AST),total bile acid (TBA),total bilirubin (TBIL) on the determination of intrahepatic cholestasis of pregnancy (ICP) diagnostic value and significance.Methods:Fluorometric determination,continuous monitoring method to tested concentration in the serum CG.Determination of alanine aminotransferase by lactate dehydrogenase method.Determination of aspartate aminotransferase by a malic acid dehydrogenase method.Enzymatic cycling method to tested concentration in the serum TBA.Serum total bilirubin was determined by vanadate oxidation method.Results:Intrahepatic cholestasis of pregnancy in patients with serum CG,ALT,AST,TBA,TBIL results were significantly higher than normal pregnant women in Xinjiang Uygur,the differences were statistical significance (P＜0.01).Through the comparison of perinatal outcomes in different groups,maternal premature birth,meconium stained amniotic fluid,neonatal asphyxia and fetal distress rate in ICP were25％,36.538％,15.385％,44.231％.There were higher than normal pregnant,the differences were statistical significance (P＜0.05).Conclusion:The determination of serum CG,ALT,AST,TBA,TBIL on intrahepatic cholestasis of pregnancy (ICP) have an important significance,especially for protection of maternal and child health.