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目的:探讨COX-2的表达与卵巢癌生物学关系。方法:采用免疫组化SP法,分别测定12例正常卵巢组织、16例良性卵巢肿瘤、70例卵巢癌组织中COX-2的表达。结果:70例卵巢癌组织中COX-2阳性表达62例,明显高于正常卵巢组织,COX-2与临床分期、及淋巴结转移均有一定关系,与病理类型无关。结论:COX-2与卵巢癌的发生、发展及转移有关,可作为观察卵巢癌进展的重要指标。
Objective: To investigate the relationship between COX-2 expression and ovarian cancer biology. Methods: The expression of COX-2 in 12 cases of normal ovarian tissue, 16 cases of benign ovarian tumor and 70 cases of ovarian cancer was detected by immunohistochemical SP method. Results: The positive expression of COX-2 in 70 cases of ovarian cancer tissues was significantly higher than that of the normal ovarian tissues. There was a relationship between COX-2 and clinical stage and lymph node metastasis, but not with pathological types. Conclusion: COX-2 is associated with the occurrence, development and metastasis of ovarian cancer, which may be used as an important index to observe the progress of ovarian cancer.