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目的 探讨大鼠局灶性脑缺血 /再灌注后脑组织内血管内皮细胞生长因子 (VEGF)的表达及意义。方法 制备大鼠局灶性脑缺血再灌注模型 ,应用免疫组化 S- P法检测 VEGF蛋白的表达。结果 缺血再灌注损伤后 VEGF表达增加 ,随再灌注时间的延长 ,在缺血灶周边区 ,阳性表达的小血管数量明显增多。结论 脑缺血再灌注损伤可以诱导 VEGF表达增强 ,VEGF可促进毛细血管增生。
Objective To investigate the expression of vascular endothelial growth factor (VEGF) in brain tissue and its significance after focal cerebral ischemia / reperfusion in rats. Methods Focal cerebral ischemia-reperfusion model was established in rats. The expression of VEGF protein was detected by immunohistochemical S-P method. Results The expression of VEGF increased after ischemia-reperfusion injury. With the prolongation of reperfusion time, the number of positive vessels in the peripheral zone of ischemic lesions increased significantly. Conclusion Cerebral ischemia-reperfusion injury can induce VEGF expression enhanced, VEGF can promote capillary proliferation.