Autologous fibroblasts induce fibrosis of the nucleus pulposus to maintain the stability of degenera

• 作 者: Chen Chen Tangjun Zhou Xiaojiang Sun Chen Han Kai Zhang Changqing Zhao Xunlin Li Haijun Tian Xiao Yang Yifan Zhou Zhiqian Chen An Qin Jie Zhao
• 机 构: Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth P
• 出 处: 骨研究（英文版）
• 发表日期: 2020年1期

INTRODUCTIONrnLow back pain (LBP) is a major cause of disability among elderly individuals and imposes substantial social and economic burden on societies worldwide.1 Lumbar/intervertebral disc degeneration (IDD) is one of the most common diagnoses involved in LBP and results in lumbar instability and height loss, which in t leads to symptomatic nerve compression, intervertebral foramen stenosis, adjacent segment degeneration, and instability-induced LBP.2