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目的 :探讨血清总胆汁酸 (TBA)测定对重症肝炎预后判断的临床意义。方法 :回顾了 44例不同预后的重症肝炎患者血清总胆汁酸水平、凝血酶原活动度 (PTA)。结果 :重症肝炎患者血清总胆汁酸水平与凝血酶原活动度成负相关性 (r=- 0 .0 1 ,P >0 .0 5 ) ;2 0例死亡患者TBA为 1 84.3± 83.2mmol/L ,2 2例存活患者TBA为 1 2 7.8±5 0 .3mmol/L ,两组比较有非常显著差异性。结论 :TBA是继PTA后又一灵敏的反映重症肝炎肝损害程度及其预后的指标。
Objective: To investigate the clinical significance of determination of serum total bile acid (TBA) in prognosis of severe hepatitis. Methods: The serum total bile acid level and prothrombin activity (PTA) were retrospectively reviewed in 44 patients with severe hepatitis with different prognosis. Results: Serum total bile acid level was negatively correlated with prothrombin activity in patients with severe hepatitis (r = - 0. 01, P> 0.05). TBA in 20 death patients was 84.3 ± 83.2 mmol / L, the TBA of 2 2 survivors was 12.8 ± 5 0. 3mmol / L, there was a significant difference between the two groups. Conclusion: TBA is another sensitive index reflecting the degree of liver damage and prognosis of severe hepatitis after PTA.