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目的 :为研究胃癌患者粘膜、血清中 β—内啡肽 (β—EP) ,P物质 (SP)、血管活性肠肽 (VIP)的变化及意义。方法 :应用放射免疫法测定 5 6例胃癌患者粘膜、血清中 β—EP、SP、VIP的含量 ,并以胃溃疡、慢性萎缩性胃炎及正常健康人为对照。结果 :与对照组比较 ,胃癌患者粘膜、血清中 β—EP显著降低 ,SP、VIP显著升高 ;粘膜与血清中 β—EP、SP、VIP呈明显正相关 ;β—EP与SP呈负相关 ,SP与VIP呈正相关 ;胃溃疡、慢性萎缩性胃炎与正常对照组比较无明显区别。结论 :联合测定粘膜与血清中 β—EP、SP、VIP揭示胃癌病人发病机理及辅助诊断有一定意义。
Objective : To study the changes and significance of β-endorphin (β-EP), substance P (SP) and vasoactive intestinal peptide (VIP) in mucosa and serum of gastric cancer patients. Methods: The contents of β-EP, SP and VIP in mucosa and serum of 56 patients with gastric cancer were measured by radioimmunoassay. The gastric ulcer, chronic atrophic gastritis and normal healthy people were used as controls. RESULTS: Compared with the control group, β-EP was significantly decreased in the mucosa and serum of gastric cancer patients, and SP and VIP were significantly increased. There was a positive correlation between mucosa and serum β-EP, SP, and VIP; β-EP was negatively correlated with SP. There was a positive correlation between SP and VIP; there was no significant difference between gastric ulcer and chronic atrophic gastritis compared with the normal control group. Conclusion : Joint determination of β-EP, SP and VIP in mucosa and serum revealed a certain significance in the pathogenesis and auxiliary diagnosis of gastric cancer.