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目的研究筛选小儿全身炎症反应综合征(SIRS)早期敏感炎症因子指标,为今后的合理早期干预提供理论依据。方法用化学发光酶免疫分析法(CLEIA)测定SIRS患儿血白介素1β(IL-1β),白介素-6(IL-6),白介素-8(IL-8),肿瘤坏死因子-α(TNFα-),采用酶联免疫吸附比色法(ELISA)测定血白介素-10(IL-10),白介素-13(IL-13)。结果SIRS患儿与对照组比较血TNFα-明显升高,血IL-6阳性率明显升高,有显著性差异(P<0.05),其他指标则无统计学意义(P>0.05)。结论血清TNFα-和IL-6是SIRS早期检测敏感指标。
Objective To study the index of sensitive inflammatory factors in early stage of systemic inflammatory response syndrome (SIRS) in children and provide a theoretical basis for reasonable early intervention in the future. Methods Serum levels of IL-1β, IL-6, IL-8 and TNFα-1 in children with SIRS were measured by CLEIA. ), Interleukin-10 (IL-10) and interleukin-13 (IL-13) were determined by enzyme-linked immunosorbent assay (ELISA) Results Compared with the control group, the serum levels of TNFα in children with SIRS were significantly increased, and the positive rate of blood IL-6 was significantly increased (P <0.05). There was no statistical significance in other indexes (P> 0.05). Conclusion Serum TNFα- and IL-6 are sensitive indicators of SIRS early detection.